Steroids and derivatives
Apexbio Technology LLC Dexamethasone phosphate disodium 2392-39-4 500mg
Dexamethasone phosphate disodium (CAS 2392-39-4) is a small-molecule agonist targeting the glucocorticoid receptor It is designed to modulate glucocorticoid-mediated signaling pathways thereby regulating immune and inflammatory responses Dexamethasone phosphate disodium exerts its biological activity primarily by binding to the glucocorticoid receptor initiating nuclear translocation and influencing gene transcription to suppress the expression and secretion of pro-inflammatory cytokines and chemokines Based on these pharmacological properties dexamethasone phosphate disodium holds research potential in studying inflammatory conditions immune response processes and associated signaling cascades in vitro and in vivo
Medchemexpress LLC Velmupressin acetate | 1647120-04-4 | 99.5% | 1006.63 | 10 MG
Velmupressin acetate is a potent, selective, and short-acting peptidic V2 receptor (V2R) agonist. It exhibits high affinity for both human (hV2R) and rat (rV2R) V2 receptors, with EC50s of 0.07 nM and 0.02 nM respectively. This product is intended for research purposes only.
- Potent and selective V2 receptor agonist
- Short-acting peptidic compound
- High affinity for human and rat V2 receptors
- For research purposes only
Apexbio Technology LLC Estrone sulfate potassium 1240-04-6 10mg
Estrone sulfate potassium (1240-04-6) is a small-molecule modulator targeting kinase activities implicated in estrogen signaling pathways It is designed to regulate estrogen-mediated biological processes by modulating specific kinase activities thereby influencing cellular responses related to steroid signaling Estrone sulfate potassium exerts its biological activity primarily through modulation of kinase pathways associated with estrogen signaling Laboratory studies indicate that estrone sulfate potassium can influence cellular responses via targeted kinase inhibition pathways Based on these pharmacological properties estrone sulfate potassium holds research potential in elucidating pathological mechanisms and identifying therapeutic targets related to endocrine disorders
Apexbio Technology LLC Estrone 53-16-7 10g
Estrone (53-16-7) is a naturally occurring estrogen that modulates estrogen receptor-mediated signaling pathways It is primarily synthesized in ovarian and adipose tissues and participates in the regulation of estrogen-dependent cellular and physiological processes Estrone exerts its biological activity primarily through binding and activating estrogen receptors Experimental model activity type and key metric (IC50/EC50) are not specified Based on these pharmacological properties estrone holds research potential in studies of estrogen receptor activation reproductive endocrinology menopausal hormone transitions and estrogen-dependent signaling pathways and diseases
Chem-Impex International, Inc. Chenodeoxycholic acid | 474-25-9 | MFCD00064142 | 250G
Chenodeoxycholic acid, 474-25-9, MFCD00064142, 250G
Medchemexpress LLC Bazedoxifene (acetate) | 198481-33-3 | 99.9% | C32H38N2O5 | 200 MG
Bazedoxifene acetate (TSE-424 acetate) is an oral, nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. It can be used for the research of osteoporosis. Bazedoxifene acetate also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer.
- Oral, nonsteroidal selective estrogen receptor modulator (SERM)
- IC50s of 23 nM and 99 nM for ERα and ERβ
- Useful for the research of osteoporosis
- Acts as an inhibitor of IL-6/GP130 protein-protein interactions
- Useful for the research of pancreatic cancer
Medchemexpress LLC Petrelintide acetate | 99.8% | 4191.69 | 10 MG
Petrelintide (ZP8396) acetate is a dual amylin and calcitonin receptor agonist (DACRA). It causes a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, leading to a loss of fat mass and preservation of lean mass during weight reduction. Petrelintide acetate can be used in diabetes research.
- Dual amylin and calcitonin receptor agonist (DACRA).
- Elicits a selective reduction in high-fat diet intake in DIO rats.
- Accompanied by a loss of fat mass and preservation of lean mass during weight reduction.
- Can be utilized in diabetes research.
Medchemexpress LLC Phytanic acid-d3 | 1383920-40-8 | 99.1% | 315.55 | 1 MG
Phytanic acid-d3 is the deuterium-labeled Phytanic acid. It is an endogenous metabolite found in blood. This compound can be utilized as a tracer and an internal standard for quantitative analysis, and is also explored for its potential impact on pharmacokinetic and metabolic profiles.
- Deuterium-labeled form of Phytanic acid
- Useful for research related to Zellweger Syndrome, Alpha Methylacyl CoA Racemase Deficiency, Rhizomelic Chondrodysplasia Punctata, and Infantile Refsum Disease
- Can serve as a tracer in experiments
- Acts as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS
- Potential to influence pharmacokinetic and metabolic profiles of drugs through deuterium substitution
Enzo Life Sciences U-73343 (5 mg). CAS: 142878-12-4
Inactive analog of U-73122 (BML-ST391) which only slightly inhibits phospholipase C. May be used as a negative control. Alternative name: 1-[6-[[(17beta)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-pyrrolidine-2,5-dione. Purity: ≥98% (HPLC). Solubility: Soluble in methylene chloride or chloroform; slightly soluble in DMSO (2mg/ml) or 100% ethanol (1mg/ml); sparingly soluble in aqueous solutions. Long Term Storage: Ambient.
Apexbio Technology LLC Estradiol Benzoate 50-50-0 1g
Estradiol benzoate (50-50-0) is a small-molecule agonist targeting estrogen receptors exhibiting high binding affinity for estrogen receptor alpha (ER ) It is designed to activate ER thereby modulating estrogen-mediated signaling pathways and hormonal regulation processes Estradiol benzoate exerts its biological activity primarily through ER agonism In in vitro assays involving human murine and chicken ER proteins estradiol benzoate demonstrates agonistic activity with an IC50 value ranging between 22 28 nM Based on these pharmacological properties estradiol benzoate holds research potential in studies of ER-mediated signaling endocrine-related diseases receptor-ligand binding analyses pharmacological screening and investigations of estrogen-dependent physiological and pathological conditions
Medchemexpress LLC 7-Methylguanosine-d3 | 20244-86-4 | 98.5% | 301.29 | 1 MG
7-Methylguanosine-d3 is a deuterium-labeled variant of 7-Methylguanosine, which functions as a cNIIIB nucleotidase inhibitor with an IC50 value of 87.8 ± 7.5 μM. Deuterium-labeled compounds are frequently used in drug development as tracers for quantitative analysis, and deuteration can influence the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer.
- Can be an internal standard for quantitative analysis through techniques such as NMR, GC-MS, or LC-MS.
- Deuterium substitution may affect pharmacokinetic and metabolic profiles.